Cathlicism

4)In proliferation of b booths , a stem carrell interacts with the stroma cadres in the rustle marrow. Cytokines from non lymphoid cell signals promotion of cell survival and leavening proliferation early in the b cell linage. Chromosome 14 codes for the corpulent chain rearranges from the germ line. A d- J particles rearranges and join to undertakeher forming dj unit at pro b stage. Makers such(prenominal) as cd 19 cd10 are place on cell to vouch maturation and proliferation. The cell differentiates from Pro b to Pre B cell. A second rearrangement fade involving v region. The v joins to the dj forming vdj segment for the slow chain. A second chromosome is rearranged forming the U chain. The pre b cell is now associated with surrogate light and U chains in conjunction with a ig a ig b complex known as pre BCR. Ig a igb attend to cell to transmit messages to the nucleus. The pre cell and so proliferates into a childlike B cell. Cd10 is drop an cd 20 is Kapp f ound on chromosome 2 and gamma found chromosome 22 rearranged, transcribed, spliced and translated to form a light chain. Allelic exclusion come ups twain grueling and light chain form either immunoglobulin M or igd. A thymus dependent reaction spend for elucidate switching, cytokines like inf y and il-5 are produce by t help cell. A second rearrangement takes place for the dark chain.

Class switching recombination happens, the unremitting region genes has s region. The cytokine stimulates everlasting mu and epsilon to be synthesis b cell then programme switch primary rna is transcribe splice pass along n a heavy(p) gamma chain do forming ! an igg. 5) cd20 is molecule that found on the surface of immature b cell. It function is to bring calcium in the cell. Calcuim is need for the activation of transcription factors for immunoglobins genes AP-1. If anti 20 molecules binds to it this mean that the second rearrangement of the heavy chain cannot occur resulting in anergy or apoptosis because the cell will cannot mature when expose to antigen. This is what Ive got so far...If you want to fuck off a full essay, order it on our website: BestEssayCheap.com

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